Electric Pants :prince_dance: (npub1qq7…fedr) Purple Cat with a PC-98 (and X68K) (npub1f8l…7frq) Mitsu (npub15xt…ywcn) I've always just used ibuprofen.
Does noticeably mess with blood pressure seemingly, and supposedly mess up your kidneys if you take too much, but it does work most of the time.
That being said, I do tend to tough out unless it's above a certain threshold.