Derek Ross on Nostr: Muting, blocking, or filtering the spam from being displayed on the client level is ...

Muting, blocking, or filtering the spam from being displayed on the client level is just a band-aid fix. Relays are still hosting the spam, using server resources.

quoting
nevent1q…gx3f

It seems like most reply guy spam is hitting the larger relays. A simple fix would be to use smaller relays and/or paid relays.