A small molecule that selectively inhibits the growth of Epstein-Barr virus-latently ...

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2024-08-21 22:10:23

A small molecule that selectively inhibits the growth of Epstein-Barr virus-latently infected cancer cells (July 2024)
https://www.cell.com/iscience/fulltext/S2589-0042(24)01806-6

They have gone through the list of FDA-approved simple meds and identified cetrimonium bromide (CetB)
(https://en.wikipedia.org/wiki/Cetrimonium_bromide), a component of some antiseptic creams, as a substance that substantially destabilizes EBNA1. This is huge, because it is the first discovered substance that does this relatively harmlessly.

EBNA1 is a protein (encoded by EBV) responsible for "stealth mode" multiplication. It enables the virus to latently "divide" with the cell, without raising suspicion. If an anomaly is detected just before division, division is cancelled (G1 arrest).

EBNA1 also evades the "antigen tagging system" which summarizes cell contents to T-killer cells. So, EBNA1 is master of hiding in the attic.

The crucial thing they showed is that their cells died from G1 arrest, not from virus lytic replication (virus pregnancy explosion).

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2024-08-21 22:10:23

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