PLOS Biology is the PLOS flagship journal in the life sciences. We are a selective, open-access, not-for-profit, peer-reviewed journal aiming to help advance discovery, depressurize the publication process and drive open science
Public Key
npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 Profile Code
nprofile1qqsru3wrrn0m78ecds69vukte8cmu2470ycuys8fjlg0jzdq69pyfjqpz4mhxue69uhhyetvv9ujuerfw36x7tnsw43qc9ff65
Show more details
Published at
2026-07-17T01:32:29Z Event JSON
{
"id": "6c84991cc8347c2d460f1de0a9f37e3336efd98e7bc879ab8c5fec91f7aba3c9" ,
"pubkey": "3e45c31cdfbf1f386c345672cbc9f1be2abe7931c240e997d0f909a0d14244c8" ,
"created_at": 1784251949 ,
"kind": 0 ,
"tags": [
[
"proxy",
"https://fediscience.org/users/PLOSBiology",
"activitypub"
],
[
"client",
"Mostr",
"31990:6be38f8c63df7dbf84db7ec4a6e6fbbd8d19dca3b980efad18585c46f04b26f9:mostr",
"wss://relay.ditto.pub"
]
],
"content": "{\"name\":\"PLOS Biology\",\"about\":\"PLOS Biology is the PLOS flagship journal in the life sciences. We are a selective, open-access, not-for-profit, peer-reviewed journal aiming to help advance discovery, depressurize the publication process and drive open science\",\"picture\":\"https://fediscience.org/system/accounts/avatars/109/310/739/948/364/624/original/f8e9b1ef35afd70e.png\",\"banner\":\"https://fediscience.org/system/accounts/headers/109/310/739/948/364/624/original/16f04d63d5eb6e5c.jpg\",\"nip05\":\"[email protected] \",\"fields\":[[\"Website\",\"https://journals.plos.org/plosbiology/\"],[\"Twitter\",\"@PLOSBiology\"],[\"Submission system\",\"https://www.editorialmanager.com/pbiology/default2.aspx\"]]}" ,
"sig": "d1e2bc5656624bf92fe8be1ecef2f3140407c13a9244f47a40a11e5a15ef3a7b91ffaa7ce05b40aff7af6614c53d4cccd6cb63fbf7f7c0424d5e2d625400979f"
}
Last Notes npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology @nprofile…63pg Here you go! https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003671 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology While it's tempting to suppose that everything that happens inside our cells has a function, Laurence Hurst explores a study in @nprofile…nznc showing that the high diversity of transcripts in mammals is down to the fact that accidents happen... Paper: plos.io/3Pcs2e6 Primer: plos.io/47Go2J2 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology In support of #OpenScience, we routinely ask authors to openly share their #research #code before publication. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How do #honeybees adapt their comb-building to different spatial constraints? A new study in #PLOSBiology uses 3D printed panels and X-ray microscopy to reveal the existence of three distinct construction modes, from tilting cells to building complex 3D structures. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology The roles of feedforward and recurrent processing in human visual object recognition are incompletely understood. This #neuroimaging and computational #modelling study in #PLOSBiology characterizes the nature of recurrent processing and how it affects object representations. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Caudal fins show great variation in shape between diverse fish species. New research in #PLOSBiology reveals that #developmental cues in embryonic tissues involving the Sonic hedgehog pathway imprint fin #morphology, highlighting a critical window for modulating appendage morphology. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology The transcription factor COUP-TFI is involved in the patterning of #hippocampus subregions. This new study in #PLOSBiology shows that COUP-TFI levels determine hippocampal compartment identity along the dorsal/ventral axis, revealing a novel #development mechanism. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology In #memories, when does bias towards or away from a stimulus arise? New research in #PLOSBiology shows that attractive serial dependence emerges during #decision-making, while repulsive biases originate during early sensory encoding. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Involuntary memories come on spontaneously and can feel vivid & emotionally powerful. This Primer highlights a recent @nprofile…0g86 study showing that involuntary & voluntary #memory recall rely on distinct neural processes. Paper: https://plos.io/4oQkb3e Primer: https://plos.io/3HJSCaU npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Myelination enables faster signal propagation in the brain, but takes more energy & space. This study reveals how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @nprofile…0g86 https://plos.io/4mq5tOy npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Involuntary memory retrieval is a common phenomenon in autobiographical #memory, and a symptom of #PTSD. This study reveals the neural mechanism of #InvoluntaryMemory, showing that involuntary & voluntary memories rely on distinct neural processes @nprofile…0g86 https://plos.io/4oQkb3e npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Early immune education mechanisms remain poorly understood. This Primer explores a @nprofile…0g86 study which uses math modeling to provide mechanistic insights into how the infant #ImmuneSystem learns to distinguish beneficial & harmful #microbes. Paper: https://plos.io/4lsJ8i5 Primer: https://plos.io/4oHrDNI npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Applying skills gained in one context to different situations enables efficient #learning, even from limited data. This Primer explores a @nprofile…0g86 study which shows that the #DefaultModeNetwork plays a key role in this ability. Paper: https://plos.io/41LOAWf Primer: https://plos.io/417aTpd npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Archaea sometimes turn against #Bacteria using hitherto unknown mechanisms. This Primer explores a @nprofile…0g86 study that reveals bacterium-killing peptidoglycan hydrolases in archaea. Paper: https://plos.io/4lrJBBa Primer: https://plos.io/3HGMYpU npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Plants have limited resources for #defense. @nprofile…k3zv explores a @nprofile…0g86 study revealing how #plants limit costs by deploying cheap traits immediately, delaying spending on costly ones until a critical damage threshold is reached. Paper: https://plos.io/45iSFUd Primer: https://plos.io/45kLk6C npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How does the developing #ImmuneSystem learn which #microbes to tolerate and which to resist? This study develops a mechanistic model of early-life interactions between the gut #microbiome & #AdaptiveImmunity, showing how immune tolerance is shaped @nprofile…0g86 https://plos.io/4lsJ8i5 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How does the #brain transfer #MotorSkills between hands? This study reveals that transfer relies on re-expressing the neural patterns established during initial learning in distributed higher-order brain areas, offering new insights into learning #generalization @nprofile…0g86 https://plos.io/41LOAWf npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Immature #neurons are found in the adult #amygdala of some mammalian species, how many are there? This study provides a detailed characterization of amygdalar immature neurons in 8 mammalian species, revealing phylogenetic variation & a high prevalence in #primates @nprofile…0g86 https://plos.io/4oClKS9 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @nprofile…0g86 https://plos.io/4fJy7YG npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Stepwise activation of #plant defense traits. This study of 6 defense traits in Ambrosia reveals that when attacked by insect #herbivores, less costly traits are induced first, while more costly traits are activated only after higher damage thresholds @nprofile…0g86 https://plos.io/45iSFUd npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Archaea-on-bacteria action! This study shows that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @nprofile…0g86 https://plos.io/4lrJBBa npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology We are proud to announce a new agreement with npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Developing motor networks rely on brief windows of plasticity. This study identifies mitochondrial #ROS & HIF-1α as instructive signals that drive lasting #neural & #behavioral changes during these critical periods, linking #metabolism to circuit development @nprofile…0g86 https://plos.io/4mHrWq4 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #NitrogenDeposition reduces #arthropod species richness & abundance, threatening #biodiversity. This study shows that natural & semi-natural habitats can buffer against these losses, emphasizing their #conservation value in mitigating N deposition’s adverseeffects @nprofile…0g86 https://plos.io/4o3RKOO npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How can magellanic #penguins navigate tidal currents while balancing #EnergyEfficiency & foraging opportunities? This study reveals how they adaptively make S-shaped return paths to their colony, optimizing travel in complex oceanic flows @nprofile…0g86 https://plos.io/40nKyD4 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Why are tetrapods with ZZ/ZW sex-determination systems more male-skewed than XY/XX?. Phylogenetic analyses of a large dataset of wild #tetrapod species reveal that #SexDetermination systems influence adult #SexRatio via sex-biased adult mortality @nprofile…0g86 https://plos.io/43qTysJ npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #AI ready health datasets can be exploited to generate many research articles of limited scientific value. Stefan Stender & @nprofile…6f4v explore a @nprofile…0g86 study describing a sudden explosion in papers analyzing the #NHANES dataset. Paper: https://plos.io/3RWgNog Primer: https://plos.io/4iTxuvq npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Vaccines are one of the greatest scientific success stories of our time. They have saved more than 154 million lives in the last 50 years — more than 1 life every 10 seconds. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology The biology and ecological impact of #phages in the mammalian gut are poorly understood. This Primer explores a @nprofile…0g86 study that provides a glimpse into the disruptive biology of the #Hankyphages, parasites of the ubiquitous Bacteroidaceae. Primer: https://plos.io/3RukgtJ Paper: https://plos.io/41Rr22S npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @nprofile…d297 &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers #plosbiology https://plos.io/3EYPZjK npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology When did the lubricated joints that allow our skeleton to swivel, rotate and bend evolve? Gage Crump explores a new #plosbiology paper by @nprofile…yvg2 @nprofile…9rr5 &co that pinpoints their origin to the earliest jawed vertebrates. Paper: https://plos.io/3CTC8La Primer: https://plos.io/4kkhXa6 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology PLOS has issued a statement on recent US Executive Orders and scientific integrity. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology In 2025, @nprofile…0g86 continues to advocate for policy based on scientific evidence. npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How to revive a collapsed mutualistic #EcologicalNetwork? @gaurav_Kbaruah &co use signal propagation theory & eco-evo model based on 115 empirical plant-#pollinator networks to reveal that effort should be focused on one or a few key species #PLOSBiology https://plos.io/3zLV0tU npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology What happens to the fitness of mammalian populations when you remove #NaturalSelection? This study uses a #MutationAccumulation experiment in mice to show that the rate of fitness loss should not be of concern, which may reassure humans... #PLOSBiology https://plos.io/3ZGXOmz npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Dopamine signaling has been linked to #analgesia & #placebo effects, but is there a causal relationship? @bingellab &co show that enhancing #dopaminergic tone does not alter generation of positive treatment expectations or placebo analgesia #PLOSBiology https://plos.io/3ZC1Exf npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Genes that affect SARS-CoV-2 infection: @Jeremie_Le_Pen @RiceLaboratory &co use genome-wide #CRISPR KO screen to identify 28 genes that impact #SARSCoV2 infection, including PLSCR1, which restricts spike-mediated #virus entry IFN-independently #PLOSBiology https://plos.io/3XYd0up npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How do network modules in the human #brain develop? #Neuroimaging of functional #connectome maturation during #childhood & #adolescence in >300 children reveals its overlapping architecture, associated with structural properties @HeLabBNU #PLOSBiology https://plos.io/3MQ8sje npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How can we track the heterogeneity & dynamics of #organelles? @MizLabUT &co present a multi-parametric, fluorescence #spectroscopy method that allows simultaneous visualization of a wide array of organelles in different maturation states #PLOSBiology https://plos.io/4gFeJfs npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Some ancient divergences in #Opisthokonta (animals, fungi & their unicellular pals) remain contentious. Hongyue Liu @RokasLab Yuanning Li &co present a genome-scale #phylogeny & establish the geological timeline of #opisthokont diversification #PLOSBiology https://plos.io/3XrOD6U npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Apicomplexans need specialized structures to invade host cells & replicate. @petersmback @GEWard14 @ToxInLA &co show that alveolin protein IMC6 is crucial for maintaining cellular morphology, invasion & successful replication in #Toxoplasma #PLOSBiology https://plos.io/3BgjxaE npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Refeeding after #fasting can lead to a "#FatOvershoot." @goldstein_lab @cumminslab &co examine the kinetics of #refeeding-induced transcriptional & chromatin changes, revealing a #lipogenic overshoot program regulated by the TF LXRα #PLOSBiology https://plos.io/4eukvi5 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Beta-band #oscillations regulate maintenance & deletion of #WorkingMemory representations in humans. This study shows that the WM performance of older adults can be predicted by beta-band neural variability during working memory deletion #PLOSBiology https://plos.io/3B8yw6y npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Integrating neuroimaging & molecular #brain data. @capra_lab @mika_rubinov &co present a resource that estimates genetically regulated components of #GeneExpression and infers associations of these with #neuroimaging & clinical phenotypes #PLOSBiology https://plos.io/3BidIcL npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology The #malaria parasite #Plasmodium undergoes a unique #endomitosis during male gametogenesis. @Zeeshan_M @RitaTewari &co show that NEK1 kinase is vital for MTOC function & chromosome segregation, facilitating rapid endomitosis in Plasmodium #PLOSBiology https://plos.io/4e4MzJ3 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Apicomplexan #parasite division: @MGissot &co show that the #phosphatase TgPP1 in #Toxoplasma regulates the #CellCycle & amylopectin accumulation by dephosphorylating inner membrane complex & starch-binding domain proteins #PLOSBiology https://plos.io/3XwMYgj npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology The kākāpō is an endangered #parrot endemic to NZ. @LaraUrban42 @HernMoral & co's study of most living #kakapo shows that their green vs olive #feather color #polymorphism has a structural basis and may result from past predation #PLOSBiology https://plos.io/4daSv1Z npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology The #brain is anatomically organized in columns, but how do these relate to function? This study reveals that the human #SuperiorTemporalGyrus is functionally organized in ~1.7-mm-diameter modules that process #language information #PLOSBiology https://plos.io/3XMMYdx npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How do integrins and paxillin interact at #FocalAdhesions? This study presents a 3D structure of the LIM3 domain of #paxillin, revealing a direct association between paxillin and the cytoplasmic tail of the #integrin beta subunit #PLOSBiology https://plos.io/3TrtFUw npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How is cell basal geometry is regulated during epithelial #morphogenesis? @PichaudLab &co show that a pathway involving #laminin & #integrin adhesion coordinates remodelling of #EpithelialCell shape by patterning their basement membrane #PLOSBiology https://plos.io/4e457co npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology 53BP1 regulates gene expression for #tumor suppression & #neural development, how is it regulated? This study shows that phosphorylation of 53BP1 by #ATM kinase is crucial for modulating genetic programs in neural progenitors & cortical #organoids #PLOSBiology https://plos.io/3XKEm70 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Vibrio coralliilyticus is a pathogen of #coral & #shellfish. @DrDorSalomon &co show it has two #T6SS systems that are activated at high temperatures. One targets bacterial rivals; the other launches 9 novel toxins against eukaryotic hosts #PLOSBiology https://plos.io/3Tvxw2B npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology What establishes the boundary between the two sections of a #spider's body plan (#cephalothorax & #abdomen)? This study identifies a new gene named "waist-less" (an Iroquois paralogue) that is required for patterning the spider body plan #PLOSBiology https://plos.io/478Wn1T npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Bemnifosbuvir (AT-527) & AT-752 are #antiviral guanosine analogues currently in clinical trials. This study reconstitutes their intracellular 5-step enzymatic activation pathway, characterizing each #enzyme complex at atomic resolution #PLOSBiology https://plos.io/3WVSAjG npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Inhibitory circuits in the #OlfactoryBulb shape info on its way from peripheral receptors to the cortex downstream. @NNUrban &co show that fast-spiking #interneurons perisomatically inhibit projection #neurons in the OB via synaptic detonation #PLOSBiology https://plos.io/4cFxDiV npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How do cells respond to defects in nuclear reassembly after #mitosis? This study in #Drosophila shows that damaged cells are either removed by #apoptosis or activate a p53-dependent #CellCycle checkpoint to maintain tissue integrity #PLOSBiology https://plos.io/3AA4g4c npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Why are animals like #NakedMoleRat (NMR) so resistant to #hypoxia & #cancer? This study shows that embryonic fibroblasts from NMRs overexpress #histone 1.2, reducing #tumor formation via the NRF2/P62 pathway & improving resistance to hypoxia #PLOSBiology https://plos.io/4fYjAbd npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology What's the role of #metabolism in bacterial persistence during infections? @rug_lrs &co show that host-specialized metabolic adaptations in #Pseudomonas aeruginosa reduce virulence & immune responses in #CysticFibrosis patients #CF #PLOSBiology https://plos.io/4dZFusF npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology ~60% of germ cells in #Celegans hermaphrodites are eliminated in meiotic prophase to maintain tissue homeostasis, but how? This study shows that size of meiotic #GermCells is reduced by apical #actomyosin constriction, leading to #apoptosis #PLOSBiology https://plos.io/4g4hpTE npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology During chronic #inflammatory diseases, how are neutrophils recruited to inflamed #skin? @PierreCoulombe8 @parentclab &co show that repeated acute stress to the skin amplifies a #neutrophil infiltration response involving keratin 17 & PKCα #PLOSBiology https://plos.io/3WVA62O npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How do #LipidTransferProteins (LTPs) coordinate exchange of #lipids between different cellular organelles? @LabVanni &co study unrelated #LTPs, identifying conserved mechanisms of lipid transfer that correlate with conformational properties #PLOSBiology https://plos.io/3XbcQzq npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How can we assess the efficacy of #tuberculosis #vaccine candidates to prioritize for larger scale trials? This novel non-invasive skin challenge model uses fluorescent #BCG to enable measuring of vaccine-induced immune responses #PLOSBiology https://plos.io/4dvTASK npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology GFP-tagging #tubulins is useful but can interfere with their cellular functions. This study describes a strategy guided by #AlphaFold2 structural predictions to label endogenous tubulins across diverse species while preserving functionality #PLOSBiology https://plos.io/3ArvolQ npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Hedgehog (Hh) signaling: @Myers_lab shows that GPCR kinase 2 (GRK2) activates SMO in #PrimaryCilia, allowing its binding to PKA-C and Hh pathway activation in various cellular & in vivo models #PLOSBiology https://plos.io/3AGYGgk npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Stomatal development: @stanfordstomata &co analyze transcriptional regulation in #Arabidopsis during #stomata development, revealing that cell fate decisions depend on interactions between master bHLH TFs and the epigenetic machinery #PLOSBiology https://plos.io/3SQh8K0 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Testing #significance of a correlation between time series is a longstanding challenge. @ShouGroup presents the truncated time-shift (TTS) test, a significance test that is valid as long as one #TimeSeries is statistically stationary #PLOSBiology https://plos.io/4dOvvGx npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Enteric #pathogens navigate distinct microenvironments along the #IntestinalTract. @swoodww @FinlayLab &co show that intestinal pH drives virulence & adaptive behavior during #Citrobacter infection, and is manipulated by the host #PLOSBiology https://plos.io/4dLy7Vz npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Pam16 & Pam18 are essential for #mitochondrial protein import in eukaryotes, but not in #Trypanosomes. @aschneiderlab show that TbPam16/18 have been repurposed to regulate #replication of #maxicircles within the T. brucei mitochondrial genome #PLOSBiology https://plos.io/3STOEis npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Arl2 regulates asymmetric division in fly neural stem cells via control of #microtubule growth. @HongyanWang9 &co show that, in mammalian #cortex, Arl2 binds to Cdk5rap2 to control microtubule growth, so regulating #corticogenesis #PLOSBiology https://plos.io/4dqDo5q npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology .@DeslippeJulie explores a #PLOSBiology study that finds complementarity of above- & below-ground #biodiversity, & a trade-off between fungal & plant richness in driving #grassland #ecosystem multifunctionality with aridity. Primer: https://plos.io/3SS8quv Paper: https://plos.io/3M69G9x npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Quality & longevity of CD4+ #Tcells change with age in mice. @AYatesGroup &co show that these cells have longer lifespans and become more quiescent when the organism ages, but these properties depend on cellular age, not on host age #PLOSBiology https://plos.io/46PBjgX npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Pancreatic ductal #adenocarcinoma (PDAC) is a deadly #cancer. @RoLiefke &co show that chromatin regulator SAMD1 represses EMT-related genes, inhibiting cellular migration, and is downregulated during #PDAC progression by #E3ligase FBXO11 #PLOSBiology https://plos.io/4crkx94 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Grasslands are key to maintaining #biodiversity & #EcosystemServices under climate change. @Prof_Braj_Singh &co show that plant & #SoilMicrobe diversity independently predict a unique portion of variation in above/below-ground functioning #PLOSBiology https://plos.io/3M69G9x npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology One's emotional response to music can change with one's #cognitive state. @mokazuma @zatorrelab reveal that pleasure from #music is in part determined by the state of resting #auditory-#reward brain networks prior to listening #PLOSBiology https://plos.io/3AvzPfq npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Cell tracking analysis made easier... @gomez_mariscal @JwPylvanainen @guijacquemet &co present #CellTracksColab, a transformative solution for #CellTracking analysis, combining cutting-edge computational methods with a user-friendly interface #PLOSBiology https://plos.io/3WEqOIr npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Larger-bodied organisms predominate in colder areas ("#BergmannsRule"). @wwAAAddddEEE @AdamSiepielski & @sinkingdiatom show that in #diatoms, #genome size, rather than cell size, is a strong predictor of species abundance in the polar oceans #PLOSBiology https://plos.io/4cm5WeK npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Effective management of #Salmonella infections requires understanding its dynamic evolution. @simrankushwaha @NobregaFL &co reveal how specific genomic regions influence the distribution of #pathogenicity factors in Salmonella #PLOSBiology https://plos.io/3WAHZdT npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Bacterial #pathogens often exploit host factors to enhance their infectivity. This study shows that #Salmonella Typhimurium boosts host #polyamine production, which is crucial for expression & needle assembly of its type 3 secretion system #PLOSBiology https://plos.io/3WRzIUb npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How do #fungi find nutrients? @NTfungalcell &co use a microfluidic device to show that #Aspergillus nidulans hyphae show #chemotropism towards nutrients, growing towards carbon sources and away from nitrogen sources & low pH #PLOSBiology https://plos.io/3Yr7gtv npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Most experimentally determined 3D #RNA structures lack functional annotation. @beakerbreaker &co present #FURNA, a database of RNA structures with high-quality annotations to enable discovery of RNA functions from structural & sequence info #PLOSBiology https://plos.io/4fkY5kp npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How do #phages impact #Streptomyces physiology? @BuryMone &co show that induction of the #prophage 'Samy' enhances dispersal of #multicellular aggregates of S. ambofaciens #bacteria in response to stress, likely promoting lineage propagation #PLOSBiology https://plos.io/3LDRNib npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology https://plos.io/4dduEiq npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology How "open" are "best paper" awards? @itchyshin &co use cross-disciplinary data to explore the level of #transparency of publicly available awards, finding that they may propagate existing #reproducibility crises & inequities in science #PLOSBiology https://plos.io/3LEmEes npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Intercellular communication is crucial for formation of the #TrigeminalGanglion. @PstroblM &co reveal that miR-203 is secreted by #NeuralCrest cells in #ExtracellularVesicles and taken up by #placode cells, regulating their condensation #PLOSBiology https://plos.io/3Lxz5sy npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Therapeutic potential for metabolic dysfunction-associated #steatohepatitis (#MASH)? This study shows that nicotinic #acetylcholine receptor (CHRNA2) signaling serves as a protective mechanism against extended metabolic stress in the #liver #PLOSBiology https://plos.io/46hnBmr npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Genomes from single #flies! Sequencing of lab-cultured species results in taxon sampling bias. @Bernard_Y_Kim @PetrovADmitri &co assemble #genomes of 183 single wild-collected #drosophilids & inbred lines, redressing the bias to lab organisms #PLOSBiology https://plos.io/3zS3Fe4 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology This study shows that #Celegans worms lacking #touch sensation show cautious-like behaviors, indicating that touch #neurons provide info not only re presence/absence of touch stimuli, but also re unavailability of touch information #PLOSBiology https://plos.io/46d7PZZ npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Existing #Cas12a nucleases are too large for #AAV-based #GeneTherapy. @grimmlab explores a #PLOSBiology study of a new Cas12a variant, compatible with in vivo #GenomeEditing via all-in-one AAV delivery. Paper: https://plos.io/3UWqpjC Primer: https://plos.io/4fmjk5F npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Detailed maps of >100,000,000 American #trees. @ben_weinstein &co provide individual tree species maps for 24 sites in the US National Ecological Observatory Network (NEON), covering 80 tree species and 100 million individuals #PLOSBiology https://plos.io/4cOej46 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Impaired neuronal connectivity and #autism spectrum disorders (#ASD). This study links the ASD-related gene #Tbr1 to impairments in #connectivity of the basolateral #amygdala & whole-brain synchronization in an ASD mouse model #PLOSBiology https://plos.io/3Sai5fK npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #RNAviruses mutate rapidly, but natural selection concentrates this variability. @bealro @RonGellerLab &co measure effects of >40,000 mutations across the #coxsackievirus B3 proteome, revealing significant variation within & between proteins #PLOSBiology https://plos.io/3W9SR23 npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Selective attention helps us overcome our brain's limited processing capacity, but how? This #neuroimaging study shows how #SelectiveAttention transforms #memory representations to reduce interference and support long-term memory #PLOSBiology https://plos.io/3Sa9eKO npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Sensitization of #AdenylylCyclase contributes to #DrugDependence. This study shows that KCTD proteins regulate this process via Cullin3 neddylation, and that this pathway in the PVT is crucial for regulating #morphine dependence #PLOSBiology https://plos.io/4cFpAnf npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology Ancestral immunity: @EnzoZ_P @AudeBer &co explore the concept of ancestral #immunity - the set of immune modules (domains & proteins) conserved between #prokaryotes & #eukaryotes - including a putative evolutionary scenario for its existence #PLOSBiology https://plos.io/4cJNLRm npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology In some #bacteria, #MutationRate depends on environmental factors (e.g. pop'n density). Why? @RowanCallumGre1 @Rok_Krasovec @knightjjar &co show that denser microbial populations detox their environment more efficiently, reducing mutation rate #PLOSBiology https://plos.io/3S8qQXy npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology .@KirstenBohmbach & @HennebergerLab explore a #PLOSBiology study showing that prolonged activation of #astrocytes can trigger cognitive impairments and a reactive phenotype, as seen in some brain diseases. Paper: https://plos.io/3LiknWp Primer: https://plos.io/3LmyOZz npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #FearGeneralization is a maladaptive response to harmless stimuli, characteristic of #PTSD. This study shows that competition between #engram & non-engram cells in the #DentateGyrus determines whether fear generalization occurs @PKU1898 #PLOSBiology https://plos.io/3LmxAgH npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology #Proteasome regulation is disrupted in human #NGLY1 deficiency. @nlehrbach @gary_ruvkun &co find that in NGLY1-deficient #Celegans this depends on #nucleotide availability, suggesting that nucleotide restriction might mitigate such diseases #PLOSBiology https://plos.io/4cViY3y npub18ezux8xlhu0nsmp52eevhj03hc4tu7f3cfqwn97slyy6p52zgnyqg3mzt8 PLOS Biology .@KaylaStoy & @wc_ratcliff explore a #PLOSBiology study which shows that #multicellular #magnetotactic #bacteria form obligately multicellular consortia of genetically diverse cells with rudimentary division of labor Paper: https://plos.io/460zcGC Primer: https://plos.io/3LnqVD1
