Simplifying Synthesis (Unofficial)

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Unofficial automated RSS/Atom links from the source Simplifying Synthesis, covering organic chemistry and total-synthesis research. Original creators are credited at the source; follow original links. Zaps support the independent feed operator, not the source creators.

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Last Notes

2026-11-01 07:35:25 GMT

Total Syntheses of Tricrilactones D and F, Crispatumine I and 2,3-trans-Crispatumine I(Brimble,2026)
An organic chemistry minilecture on the 'Bioinspired Total Syntheses of Tricrilactones D and F, Crispatumine I, and 2,3-trans-Crispatumine I' by Tashia Siew, Liam R. Hunt, Gabriel Chun Yi Ng, David Rennison and Margaret A. Brimble*. It features a Transannular Cyclisation Cascade to rapidly and efficiently construct the polycyclic framework of several biologically interesting natural products.
SUPPORT THE CHANNEL ON PATREON:
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References:
Angewandte Chemie 2023, 135, DOI 10.1002/ange.202300773 (Isolation)
Bioorg. Chem. 2026, 175,109768 (Isolation)
Org. Lett., 2017, 19, 24, 6502–6505 (IBX Mechanism)
Angew. Chem. Int. Ed.2025, 64, DOI 10.1002/anie.202419989.(Cordycicadin synthesis)
https://www.youtube.com/watch?v=1_alLXUjbKA
https://i2.ytimg.com/vi/1_alLXUjbKA/hqdefault.jpg
#totalsyntheses #crispatumine #tricrilactones #bioinspiredtotal #davidrennison #gabrielchun #tashiasiew #isolation #angewandtechemie #cyclisationcascade
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