#Neuroscientist, postdoctoral researcher studying spatial memory and flexible decision-making with #Tetrode recordings in the #Hippocampus of rats solving complex spatial tasks. This is my #Neuroscience focused account. (profile pic shows a Long-Evans rat with his paw on an old-school compass. photo by R. Grieves; header shows raw hippocampal neural activity recorded from a resting rat, with #Ripples and associated spiking)
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2026-11-07T16:38:39Z Event JSON
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Last Notes npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Hi all, Save the date: The 6th International Sleep Replay Workshop will be held in Glasgow, UK, on Monday the 26th of July 2027, just ahead of the International Conference on Memory! As always, the workshop will consist of symposia, talks, and discussion groups focused on the interface between sleep and memory. We will share registration info and additional details with the ISRW mailing list later in 2026. The workshop will start early on the 26th, so we recommend arriving in Glasgow the day before. Thinking of coming to ICOM, ISRW or both? Let me know in comments! Looking forward to seeing you there 😊 Organizing Committee for ISRW-VI James Antony (California Polytechnic State University) Eleonore Duvelle (University of Glasgow) Gordon Feld (Central Institute of Mental Health, Mannheim) Eva Kimel (University of York) Penny Lewis (Cardiff University) Eitan Schechtman (University of California Irvine) Jing Zhang (Harvard University) #Neuroscience #Research #AcademicChatter #NeuroConf #Memory #HippocampalReplay npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @nprofile…yx65 No specific reason other than I realised that I know absolutely nothing about this topic and it would be cool if the architecture of the vasculature had some link with function somehow Also I wonder if there is some kind of bottleneck in the vasculature around entorhinal cortex / hippocampus as this is where Alzheimer's seems to start and it might be caused by poor cleaning of waste which is probably performed by the blood... It's really just very vague speculations and I could do with someone pointing me to a good review on the topic npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Are there any experts of brain vasculature out here? Wondering about the general direction of blood flow in the brain... Does it vaguely follow the flow of information (sensory input --> motor output) or not at all? #neuroscience #neurovasculature npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Nice! @nprofile…z0ng wrote a blog post about our #NeuroMethods community and its recent move to #Zulip : https://gcamp6f.com/2026/07/21/neuro-methods/ We also realized this year is the 10th anniversary of Neuromethods! 🥳 I guess @nprofile…swkq 's sponsorship for their 'Standard' Plan could be considered a birthday gift, thanks again Zulip! 🙏 #Neuroscience #nevent1q…wemg npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @nprofile…yx65 thank you for sharing!! npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro ~ New preprint, new thread! ~ My former colleagues at UCL Margot Tirole and Dan Bendor (not on Masto) have a new #HippocampalReplay preprint out, to which I contributed a little! Check out our thread and don't hesitate to share and comment!Why do we remember some experiences more than others? Reactivations of neurons in the #Hippocampus (“replay”), particularly during sleep, may help consolidate memories; but when many experiences occur before going to bed, the brain must sort out what is worth replaying 😴 We investigated whether reward or recency helped prioritize experiences for replay in freely-moving rats. Surprisingly, we found that reward value does not influence replay! Instead, episode recency has a major effect, with the most recent episode being replayed the most! Check the preprint for more: Time, but not reward, shapes replay-based episodic prioritization ... or read on for a thread on the main results! ⏬ #NeuroRat #SpatialMemory #MemoryConsolidation #Neuroscience #MastoThread 1/12 🧵 https://media.neuromatch.social/media_attachments/files/116/850/187/989/937/515/original/82ca96aabd76d0e5.mp4 npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @nprofile…v9vp yes you are right this is probably related! thank you 😊 npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Dear #NeuroMasto hivemind, It feels like hard decisions are more effortful than easy decisions, not only because they take more time to make but possibly also because our brain uses more energy to take them. Anyone knows if this has ever been scientifically proven (the energetical cost of hard decisions)? #Neuroscience #DecisionMaking npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro The #Tolman "sunburst maze" results (from 1946) are often used to demonstrate shortcut ability in rats... but do they really? More on this later! For now, would you know of any #ComputationalModels that were tested in this protocol (whether they replicate the original results or not)? We know of a few (well... 4) but would like to make sure we are not missing any. #BehaviouralNeuroscience #SpatialCognition #Shortcuts #CognitiveMap #Neuroscience (kind of) https://media.neuromatch.social/media_attachments/files/114/477/536/170/350/932/original/8467d3e0966505ae.jpg npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @nprofile…cvwk Hmm doesn't fMRI measure the increased oxygenation of blood, following a surge in blood flow caused by an increase in firing in that brain region (more oxygenated blood arrives that is needed so more of it is left after going through the brain region of interest)? Take a sensory neuron that is not currently important. How does it know it's not important and fire fewer spikes? Is this actually a thing? Neurons that are "not important" fire less spikes? I would imagine that a sensory neuron that receives the same input will fire the same amount, regardless of importance. If a downstream region needs to ignore its firing then that will happen at the level of the downstream region no? What's the chain of signals and mechanisms that lead to that effect? But if I accepted your premise that non-important neurons fire less, then a mechanism for this (say, through attention or rather lack of attention) could be that the "gating" region connects back to the sensory region and lowers the baseline potential of neurons in that region, such that it takes them more excitatory inputs to fire spikes. Or it could recruit inhibitory interneurons that, well, inhibit your sensory neurons from firing as much. npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @nprofile…cvwk isn't this what fMRI measures? Neurons that are more active during a specific task use more oxygen and other resources so blood flow to these neurons increases to fill the need? Or maybe you meant that "the brain" somehow chooses which neurons should be given more resources at specific times? I'm not sure how that would work.. It seems to be more like a distributed system than a hierarchical one npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro I've said it before but the #NeuroMethods slack is really useful for all #Neuroscience methods questions. Feel free to join at https://neuromethods.slack.com/ with your institutional email, or DM me if you can't join that way! npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Please share these 2 PhD positions in #ComputationalNeuroscience co-supervised by Dr. Elisa Massi #ETIS Lab -- CY Cergy Paris Université (France): They both start from September 2025, but the application deadline is on the 30th of January 2025 SMaRT-RL: Stress & Hippocampal Replay in Reinforcement Learning: https://dim-cbrains.fr/en/phd-program/dim-cbrains?search=canamero SYSNEMEHISPIN: Memory Formation with Spiking Neural Models: https://www.dim-cbrains.fr/en/phd-program/dim-cbrains?search=manos Interested candidates can apply after their registration on the DIM C-BRAINS platform: https://dim-cbrains.fr/en/platform/login These are funded for 3 years, the normal PhD duration in France. These scholarships aim at enhancing international mobility and are reserved for candidates that have recently studied or worked outside France. #Neuroscience #PhDPosition #FindAPhD npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro This month is my #PhDThesis Anniversary of... 10 years! 🎓 In case anyone wants to have a look it can be downloaded there: Role of the hippocampus in goal representation : insights from behavioural and electrophysiological approaches Yes I probably thought at the time that 10y from then I would have a permanent position, a house, maybe a family and at least a few pets... but I find it hard to settle somewhere "for the rest of your life"... maybe that's why I study spatial decision-making 😅 Leaving you with my favourite quote (source unknown): time flies like an arrow fruit flies like a banana #PostdocLife #Academia #Research npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro I keep seeing studies (especially computational ones) citing the Ambrose et al. 2016 paper as proof that #HippocampalReplay is modulated by reward. I don't think this result can be trusted... The time spent at low-speed at reward sites wasn't controlled. Rats left the less rewarded sites much faster, and would probably move a lot more when less reward was present (not analyzed I think). The amount of ripples or replay is analysed in count per second. I believe this means seconds of any kind of behaviour, not just rest or low speed. But #Ripples and the related #Replay only happens when the rat is quasi-immobile. At low speed you might have 1 replay per second, while when moving it will be 0/s. A recent preprint (Mallory et al., 2024) suggests that after a few seconds at a reward location, reverse replay dominates. Ambrose et al. specifically show an increase of reverse replay for the x4 reward vs x1 reward. If rats indeed spent more time at the most rewarded location, they would be in reverse replay mode, fully explaining the results without the need to invoke any kind of value processing. Note: the reduced replay result was not specific to reverse replay for 1 vs 0, probably because the rats didn't stay immobile long enough to get some of those forward replays during the earlier reward period. I might have missed something (if so let me know) but I am now completely unconvinced by the 2016 paper. What do you all think? #Hippocampus #ValueCoding Edit: added some more info after re-reading the 2016 paper npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Hi all, please could you share this PhD studentship offer with anyone relevant? From my colleague Ana Gonzalez-Rueda (lecturer at the #UniversityOfGlasgow): "My new lab at the University of Glasgow has a fully-funded* PhD position open for applications!! The project will explore how neuroinflammation causes cognitive deficits such as “brain fog” by using a combination of behavioural assays, high-density electrophysiology and targeted interventions in a neuroinflammatory mouse model. Link for more info Please do not hesitate to contact me if you have any questions: [email protected] Deadline 12th of January 2025 (*)Unfortunately, UK residents eligible for home fees only" #Neuroscience #NeuroJob #NeuroMouse npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Someone in my uni is asking what do people think of the Journal of Cognitive Neuroscience for submitting papers - do they have a good review turnout and reasonable criteria for publication? #CognitiveScience #Publication #Academia npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @npub1skv…aky3 ♥️🤗 npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @npub1skv…aky3 very cool, thanks for sharing all these! npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Are there any grants that you can apply to at the #postdoc stage to do data analysis? #Academia #Neuroscience npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @npub1skv…aky3 thank you Nicole! ☺️ npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro The last #HyperDriveI’ll be building here in the US! (I’m leaving my current postdoc in 6 weeks to go on holidays and then maybe another postdoc in Glasgow!) #PostDocLife https://neuromatch.social/system/media_attachments/files/112/317/904/272/785/353/original/ee74403536ef4c52.jpeg npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @npub19d9…f02p not an expert but isn’t consciousness also about immediate sensations and not just memorized events? Like, I get hurt by something, I am then conscious of the pain, or even if I’m staying immobile doing nothing and trying to think of nothing.. I am conscious of breathing and sitting on the couch? For me consciousness is just the neural activations happening in your brain that are coherent enough that they pass a threshold for you to be aware of it. Sensation, memory, action, could be anything… npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Submitted my first fellowship application as a #Postdoc! (what, it’s never too late…) 🥳 npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro What is the difference between Behavioural #Neuroscience and #NeuroEthology? 🧠 npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro @npub1skv…aky3 I hope you're letting them know they should come here for the real stuff ;) npub1svsluu56v7rh2e9rmwq43njz2a97hg92hpu5sq8atz6zvqszf89qe9rgc7 El Duvelle Neuro Welcome to all! ❤️🐀 Potential new followers: can we try something out? - if you're a #Neuroscientist (of any status, yes, undergraduate students can be neuroscientists), could you answer with your neuro 'categories': Experimentalist, Computational, Philosopher, Fly, Human, Rodent, Whale, Tetrodes, Calcium imaging, fMRI, EEG, etc. This is so that I (and possibly others) can put you in a List! I'll share my lists once they have grown enough 😀 - if you're not a Neuroscientist, this account will probably not follow you, but you are totally free to follow it, and also to tell us about you and any questions you might have about neuroscience! - if you want to learn about neuroscience, I will try to post beginner-level explanations with the hashtag #NeuroForNewbies. Just an experiment...